White Blood Cells

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Eosinophil

Eosinophils are one of the five different types of white blood cells belonging to the subgroup called Polymorphonuclear Leukocytes. Eosinophils are produced in the bone marrow and then migrate to tissue, and they are characterized by large red cytoplasm granules. These cells have the purpose of giving large parasites such as helminths, a hard time. They attach via Cb receptors, the Cb having been produced during the course of alternative pathway complement activation by the helminth. The eosinophils release various substances from their granules. These include major basic protein plus cationic proteins, peroxidase, arylsulphatase B, phospholipase D and histaminase. The granule contents are capable of damaging the parasite membrane. Eosinophil function is incompletely understood. They are prominent at sites of allergic reactions and with parasitic larvae infections ( helminths ). Eosinophil secretory products inactivate many of the chemical mediators of inflammation and destroy cancer cells. This phenomenon is most obvious with mast cell-derived mediators. Mast cells produce a chemo tactic factor for eosinophils. When a foreign substance enters the body, lymphocytes and neutrophils release certain substances to attract eosinophils which release toxic substances to kill the invader.

Neutrophils

Neutrophils respond to chemo tactic signals and leave capillaries by a complex process, involving margination, rolling and then attaching, following which they emigrate between the endothelial cells (extravasation, or diapedesis). Several mediators are involved. They include substances produced by micro-organisms, and by the cells participating in the inflammatory process. One such is a substance called interleukin-1 (IL-1), which is released by macrophages as a result of infection or tissue injury. Another is histamine, released by circulating basophils, tissue mast cells, and blood platelets. It causes capillary and venular dilatation. Ca and C5a produced during complement activation are chemo tactic for phagocytic cells. Another group of substances produced are the acute phase proteins. As a result of tissue damage, the liver produces a substance called C-reactive protein. This activates the complement system by the classical pathway, and as a result Ca is formed and coats the organism, facilitating its phagocytes. Custom writing service can write essays on White Blood Cells

The peripheral immune system is activated and neutrophils from the bone marrow enter the blood. This increase in neutrophils will make more neutrophils present at the site of the injury. It is believed that these neutrophils cause damage to the axons of the nervous system. Neutrophils also make enzymes that kill bacteria, but also kill tissue which leads to damage of the nervous system.

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